Background: Alopecia areata is the hair loss usually reversible, in sharply defined areas. The treatment of alopecia\r\nusing growth factors shows interesting activity in promoting hair growth. In this concept, VEGF (vascular\r\nendothelial growth factor) is a marker of angiogenesis, stimulating hair growth by facilitating the supply of nutrients\r\nto the hair follicle, increasing follicular diameter. The aim of this study was the evaluation of a topical gel enriched\r\nwith VEGF liposomes on the hair growth stimulation and its toxicological aspects.\r\nMethods: Mesocricetus auratus were randomly divided into three groups. Control group was treated with\r\nAristoflexW gel, 1% group with the same gel but added 1% VEGF and 3% group with 3% VEGF. Biochemical,\r\nhematological and histological analyses were done.\r\nResults: At the end of the experiment (15th day of VEGF treatment) efficacy was determined macroscopically by\r\nhair density dermatoscopy analysis, and microscopically by hair diameter analysis. They both demonstrated that hair\r\nof the VEGF group increased faster and thicker than control. On the other hand, biochemical and hematological\r\nresults had shown that VEGF was not 100% inert.\r\nConclusions: VEGF increased hair follicle area, but more studies are necessary to confirm its toxicity.
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